Human Epidermal Langerhans Cells Express Integrins of the β1 Subfamily
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Human Epidermal Langerhans Cells Express the High Affinity Receptor for Immunoglobulin E
From the *Laboratory of lmmunodermatology, Department of Dermatology, University of Munich Medical School, 8000 Munich 2, Germany; the ~Laboratoire d'Histocompatibilitd and Institut National de Ia Santd et de la Recherche M~dicale U.311, Centre R~gional de ~ansfusion Sanguine, 67000 Strasbour,~ France; SHoffman-La Roche Ina, Nude),, New Jersey 07110-1199; and the IIDepartment of Dermatology, Un...
متن کاملHuman epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI)
It has been suggested that epidermal Langerhans cells (LC) bearing immunoglobulin E (IgE) may be involved in the genesis of atopic disease. The identity of the IgE receptor(s) on LC remained unclear, although it represents a crucial point in understanding cellular events linked to the binding of allergens to LC via IgE. In this report, we demonstrate that epidermal LC express the high affinity ...
متن کاملA Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells
Transforming growth factor beta 1 (TGF-beta 1) regulates leukocytes and epithelial cells. To determine whether the pleiotropic effects of TGF-beta 1, a cytokine that is produced by both keratinocytes and Langerhans cells (LC), extend to epidermal leukocytes, we characterized LC (the epidermal contingent of the dendritic cell [DC] lineage) and dendritic epidermal T cells (DETC) in TGF-beta 1 nul...
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vasculitic lesions. Cell-mediated immune (CMI) dysfunction, including defective natural killer cell function has been documented in patients with XLP, and defective CMI may result in altered EBV tissue tropism as we suggest. We agree that many more patients, as well as controls, would need to be studied to definitively answer this issue. The functionality of EBV-specific CTL remains a subject f...
متن کاملDensity of epidermal Langerhans cells in psoriasis
Immunocytochemical techniques using antibodies to the specific T6 and Ia (Major Histocompability Complex, class 11, human HLA-Dr) antigens were used to determine the densities of epidermal Langerhans cells (LC) in psoriasis patients treated with the aromatic retinoid RO 10-9359. Fourteen patients were treated with the aromatic retinoid and were skin biopsied before, during and after therapy. Tw...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1991
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12470229